The objective of this article was to examine the mediating role of family-to-work enrichment (FWE) on the relationship between family support and the performance of women-owned businesses. Empirical data from 251 women entrepreneurs in South Africa were used to assess the postulated relationship. The findings showed that all three examined types of family support (i.e., emotional, instrumental and financial family support) were positively associated with firm performance. Additionally, affective FWE mediated the relationship between emotional support and performance, while instrumental FWE mediated the association between instrumental family support and performance. The study culminates with a discussion of the implications of the study, by emphasising the need for the current system to take into account the distinctive needs and challenges of women entrepreneurs and provide the necessary support and environment to foster their growth and prosperity.