The present study investigates the long-run association and direction of causality among economic growth, trade openness and gross capital formation in Brazil, Russia, India, China and South Africa (BRICS) nations. This article applied autoregressive distributed lag (ARDL) and vector error correction model to examine the long-run association and casual relationship among the competing variable. The ARDL bound test results indicate long-run relationship among economic growth, trade openness and gross capital formation. Granger causality results reveal unidirectional causality from trade openness to economic growth in India and that Brazil supports trade-led growth hypothesis while bidirectional causality is found between trade openness and economic growth in China supporting feedback hypothesis. In addition, the empirical evidence of unidirectional causality moving from economic growth to trade openness is found in South Africa validating growth-led trade hypothesis. As trade openness is a significant determinant of economic growth in BRICS, the member countries should adopt policies towards trade liberalization to sustain economic growth. Moreover, these emerging markets offer a pool of investment opportunities for the global managers.