The objective of this paper is to assess the relationship between government support programs and performance of Small and Medium Enterprises (SMEs) in Brikama region of Gambia. Three dimensions of government support programs, namely, training assistance, financial assistance and marketing assistance are analyzed to examine the relationship between government support programs and performance (proxied by sales, return on asset, return on equity, assets turnover, net profit and debt ratio) of SMEs. Using a questionnaire, 80 SMEs are sampled via stratified sampling method. Percentages and Pearson chi-square techniques are utilized to analyze the data. Among others, the study finds a statistically significant relationship between sales and training assistance. In addition, the relationships between marketing assistance and sales as well as marketing assistance and return on assets are found to be statistically significant. Further, the relationships between financial assistance and return on equity as well as financial assistance and debt ratio are found to be statistically significant. Therefore, there is a need for increased government support in order to enhance the performance of SMEs in Gambia.