Promoting spiritual health is essential for achieving holistic wellness. The modern era has recorded a sharp increase in lifestyle diseases such as high blood pressure, high blood sugar, allergic disorders, psychosomatic disorders, mental illnesses and diseases associated with low immunity. The goal of positive health for all remains unachieved as the World Health Organization (WHO) has not included ‘spiritual health’ in its definition of health. The basic pathophysiology of most of the diseases could be explained scientifically through the primary respiratory mechanism (PRM). The PRM is ‘breathe spark plug’. If strengthened, it could influence and decline occurrence of lifestyle diseases and lead to a positive health status. Recent emphasis on yoga, meditation and wellness by the Government of India are some of the available methods to achieve positive health. This article discusses the role of PRMs to understand and improve health and well-being. We propose that the inclusion of yoga and meditation in the primary health care as promoted by the Government of India is one of the best available methods to achieve positive health and holistic wellness.