Safety of employees is one of the important concerns of the manufacturing organizations and needs to be addressed carefully. It was once, not in ambit of focus but the realization of making safety management as an integral part of the organization is gaining pace. The research article attempts to study the influence of safety perception of the employees on their job satisfaction level in selected small and medium manufacturing enterprises of Uttarakhand in India. A self-developed 29 items scale was used to determine the safety level of employees and job satisfaction inventory by Paul and Spector was used for assessing the job satisfaction level of employees. Linear regression analysis was used to find the degree of influence of safety on job satisfaction level of employees. Stepwise multiple regressions were used to identify the safety factor which contributes the most for employee’s job satisfaction. The research highlights positive influence of safety perception of employees on their job satisfaction level and draws attention towards safety as predictor of job satisfaction. Training and supervision and work procedures were identified as the most contributing factors to enhance job satisfaction of the employees. This study could be helpful for organizations to identify most contributing safety factor which lead to improving the level of job satisfaction among employees.