In the article provided actuality, problems and the ways of development of National Innovative Systems (NIS) in the conditions of structural changes in economy also investigated and analyzed classifications of the national innovative system of Uzbekistan, shined prospects of further development of NIS. NIS appeared to be insufficientlyadapted for the realities of the market and mixed economy of the developed countries and consequently in the majority of developed countries. NIS evolved to the second generation of forms of the organisation. Developments of NIS make direct impact on economic growth and development of modern market economy, and in the creation of the added cost in the economy of knowledge hi-tech, knowledge intensive productions start to play a leading role. [ABSTRACT FROM AUTHOR]